ABSTRACT
Liver is the most common target for toxic injury. Toxic agents include chemicals such as carbon tetrachloride [CCl4] and trichloroethylene. This study aimed to evaluate the effect of bone marrow cells [BMC] transplantation and/or fractionated low doses [0.5 Gy] gamma radiation on established liver fibrosis induced by CCl4. BMCs of male albino rats were transplanted into 4-weeks carbon tetrachloride [CCl4]-treated and/or fractionated low doses [0.5 Gy] gamma irradiated rats through the tail vein, and the rats were treated for 4 more weeks with CCl4 [total 8 weeks]. Histological and ultrastructural investigations revealed that both bone marrow cells transplantation and low dose [0.5 Gy] gamma radiation exposure with continuous CCl4 injection had reduced liver fibrosis as compared with rats treated with CCl4 alone